2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W090446
    4-Boc-amino-2,2-dimethylbutyric acid 153039-17-9
    4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-Boc-amino-2,2-dimethylbutyric acid
  • HY-138438
    Azido-PEG3-amino-OPSS
    Azido-PEG3-amino-OPSS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-amino-OPSS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-amino-OPSS
  • HY-133367
    DBCO-NHCO-PEG6-amine
    DBCO-NHCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG6-amine
  • HY-126999
    Bis-PEG5-PFP ester 1334177-78-4
    Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG5-PFP ester
  • HY-130526
    Tos-PEG6-CH2-Boc 1530777-90-2
    Tos-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG6-CH2-Boc
  • HY-141042
    Bis-(N,N'-carboxyl-PEG4)-Cy5 2107273-44-7
    Bis-(N,N'-carboxyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-(N,N'-carboxyl-PEG4)-Cy5
  • HY-141127
    Azido-PEG4-tetra-Ac-beta-D-glucose 153252-44-9
    Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-tetra-Ac-beta-D-glucose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-tetra-Ac-beta-D-glucose
  • HY-134701
    Acetamido-PEG2-Br
    Acetamido-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acetamido-PEG2-Br
  • HY-133162
    Mal-PEG1-Boc 810677-16-8
    Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG1-Boc
  • HY-132050
    Azido-PEG4-propargyl 1192590-91-2
    Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG4-propargyl
  • HY-138328
    Benzyl-PEG18-MS
    Benzyl-PEG18-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG18-MS
  • HY-138448
    m-PEG750-Br
    m-PEG750-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG750-Br
  • HY-140064
    Propargyl-PEG1-acrylate 52436-42-7
    Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG1-acrylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-acrylate
  • HY-138343
    Azido-PEG3-MS 176520-24-4
    Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-MS
  • HY-132108
    Benzyl-PEG3-MS 702701-70-0
    Benzyl-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG3-MS
  • HY-143844B
    Bromo-PEG7-amine hydrobromide
    Bromo-PEG7-amine hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-amine hydrobromide
  • HY-140610
    Propargyl-PEG4-Sulfone-PEG4-acid 2055024-41-2
    Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Sulfone-PEG4-acid
  • HY-178512
    Piperazine-CO-C1-Azacyclohexane-C1-Piperazine
    Piperazine-CO-C1-Azacyclohexane-C1-Piperazine is a PROTAC linker can be used in the synthesis of PROTACs, such as PROTAC CDK4/6/9 degrader 1 (HY-178452).
    Piperazine-CO-C1-Azacyclohexane-C1-Piperazine
  • HY-140441
    Fmoc-aminooxy-PEG12-acid
    Fmoc-aminooxy-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-aminooxy-PEG12-acid
  • HY-168223
    Boc-Piperazine-2-F-Ph-CHO 501126-37-0
    Boc-Piperazine-2-F-Ph-CHO (Compound 2) is a PROTAC linker, used for the synthesis of YD54 (HY-168221) .
    Boc-Piperazine-2-F-Ph-CHO
PROTAC Linkers Isoform Comparison

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