2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130168
    m-PEG5-azide 1202681-04-6
    m-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG5-azide
  • HY-140155
    Methylamino-PEG2-Boc 1807521-04-5
    Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG2-Boc
  • HY-140737
    DSPE-PEG-CH2COOH, MW 2000
    DSPE-PEG-CH2COOH, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-CH2COOH, MW 2000
  • HY-140068
    endo-BCN-PEG3-NHS ester 2101206-94-2
    endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG3-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG3-NHS ester
  • HY-140321
    DBCO-mPEG (MW 20kDa)
    DBCO-mPEG (MW 20kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 20kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-mPEG (MW 20kDa)
  • HY-133458
    Biotin-PEG3-amido-SS-amido-azide 2866429-93-6
    Biotin-PEG3-amido-SS-amido-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG3-amido-SS-amido-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG3-amido-SS-amido-azide
  • HY-130380
    Propargyl-PEG7-Boc 1818294-29-9
    Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-Boc
  • HY-140022
    Propargyl-PEG14-acid
    Propargyl-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG14-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG14-acid
  • HY-159617
    Cbz-Pip-2C-Pip-C-Pip 3035215-25-6
    Cbz-Pip-2C-Pip-C-Pip is a PROTAC linker. Cbz-Pip-2C-Pip-C-Pip can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608).
    Cbz-Pip-2C-Pip-C-Pip
  • HY-132083
    Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid
    Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid
  • HY-163788
    C5-CONH-C2-N-CH3 1251346-48-1
    C5-CONH-C2-N-CH3 is a PROTAC linker that can be used in the synthesis of PROTACs.
    C5-CONH-C2-N-CH3
  • HY-138529
    Thiol-C9-PEG5 130727-42-3
    Thiol-C9-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C9-PEG5
  • HY-130384
    Propargyl-PEG6-Boc 1355197-95-3
    Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG6-Boc
  • HY-138436
    PEG2-ethyl acetate 154773-33-8
    PEG2-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG2-ethyl acetate
  • HY-140938
    Biotin-PEG3-oxyamine 1786206-22-1
    Biotin-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-oxyamine
  • HY-140181
    Amino-PEG23-acid
    Amino-PEG23-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG23-acid
  • HY-138735
    Propargyl-PEG13-OH
    Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG13-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG13-OH
  • HY-140980
    Mal-amido-PEG12-TFP ester
    Mal-amido-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-TFP ester
  • HY-168289
    12-((4-Bromobutyl)amino)dodecanoic acid
    12-((4-Bromobutyl)amino)dodecanoic acid is the PROTAC linker of MS934 (HY-153863). 12-((4-Bromobutyl)amino)dodecanoic acid can be utilized in PROTAC synthesis.
    12-((4-Bromobutyl)amino)dodecanoic acid
  • HY-140897
    Biotin-PEG6-amine 2757573-29-6
    Biotin-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-amine
PROTAC Linkers Isoform Comparison

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